Abstract:After the founding of new China, Mao Zedong linked Chinas concrete reality to implement regional autonomy for nationalities, instruct national government by law construction, support multinational area economy, develop national culture and education, and reconstruct national social order, which had constructed the basic guarantee of new Chinas national unity and progress. Mao Zedong attached importance to organization and leadership, investigation and research, propaganda and education, team construction and social concern, which had explored the effective way of new Chinas national unity and progress. In practice Mao Zedong followed scientific development, promoted social harmony and stability, advocated seeking truth from facts, carried out the mass line, adhered to an independent strategy, which had established the guidance strategies of Chinas national unity and progress.