In the decentralized management mode,due to the conflict between individual reason and knowledge creation, the enterprises’ enthusiasm of being involved in knowledge creation and their profit levels have been weakened. In order to overcome the opportunism during the knowledge creation of creative industry cluster in the process of creation, the knowledge creative industry cluster need to conduct an integrated management. By adopting the integrated management, enterprise can effectively overcome the knowledge creating moral hazard in the process of knowledge creation, and achieve the knowledge output maximization conditions, both the knowledge capital investment and profits have been significantly improved, so as to realize the collective rationality and individual rationality perfect integration.