The paper analyzes the relationship between human capital,R&D spending,economic development level and regional innovation in 30 provinces,municipalities and autonomous regions of China by the panel-data model.Human capital is divided into different classes according to different innovation subject,and its contributions to China’s regional innovation is analyzed.The results show that human capital of research institutions plays a significant role in 13 provinces and municipalities of China;human capital of enterprises plays a remarkable role in 14 provinces and municipalities of China,and human capital of university plays an important role in 17 provinces and municipalities of China.Overall speaking,the contributions of three kinds of human capital to the innovation is different in different regions.