Since the founding of the Peoples Republic of China, with the changing of the social background and politics, economy, and culture, the form of the macro-space of the distribution structure of higher educational institutions has experienced the stages of the spatial reconstruction, the spatial rupture, the spatial extension and the spatial integration. The evolvement process has prompted the macro-space form of the distribution structure of higher educational institutions constantly “reproduction”, so as to promote a sustained development of higher education. Discussing the process of the evolvement of the macro-space of the distribution structure of higher educational institutions, and summarizing the characteristics and specific performance, can help to find the inherent rules of spatial activities of higher education, and provide support for the reform and development of higher education.